ABSTRACT
Objective: This study aimed to evaluate the levels of two oxidative stress [OS] markers including lipid peroxide [LPO] and total antioxidant capacity [TAC] in both serum and follicular fluid [FF] of women with endometriosis after puncture
Materials and Methods: In this cross-sectional study, a total number of sixty-three women younger than 40 years old with laparoscopy [gold standard for endometriosis diagnosis] indication underwent in vitro fertilization [IVF] program in the Royan Institute, Tehran, Iran from September 2013 to October 2014. About forty-three patients were diagnosed with endometriosis after laparoscopy. Blood and FF from the leading follicle in each stimulated ovary were obtained at the time of egg retrieval; samples were centrifuged and frozen until assessment. At the time of sample assessment, serum and FF samples were evaluated for the levels of LPO and TAC on spectrophotometery
Results: We observed that women with endometriosis had significantly higher LPO and lower TAC levels in the serum and FF as compared with the control group [P<0.05]
Conclusion: It has observed that FF of women with endometriosis, regardless of disease stage, increases the proliferation power of endometrial cells in vitro, we presume that inflammatory reactions-induced OS in ovary may be responsible for proliferation induction ability in FF obtained from women with endometriosis